【摘要】 介绍了3,3′-二吲哚基甲烷(D IM)及其衍生物3,3′-二(5-溴吲哚)基甲烷(BB IM)和3,3′-二(5,6-二氯吲哚)基甲烷(BC IM)的合成方法。该方法以吲哚、5-溴-1-氢吲哚和5,6-二氯-1-氢吲哚为原料,在酸性条件下与N-羟甲基丙烯酰胺反应分别得到D IM、BB IM和BC IM,收率分别为90.3%、46.3%和53.3%。通过IR1、HNMR、13CNMR和元素分析对D IM的结构进行了表征,通过IR、1HNMR对BB IM和BC IM的结构进行了表征。更多还原

【Abstract】 3,3′-Diindolylmethane（DIM）,bis（5-bromo-1H-indol-3-yl）methane（BBIM） and bis（5,6-dichloro-1H-indol-3-yl）methane（BCIM） were synthesized by reaction of indole,5-bromo-1H-indole and 5,6-dichloro-1H-indole respectively with N-（hydroxymethyl）acrylamide under acidic condition in 90.3%,46.3% and 53.3% yield.The structure of DIM was confirmed by IR,¹HNMR,¹³CNMR and elementary analysis.The structures of two derivatives were confirmed by IR and ¹HNMR.更多还原