【摘要】 以甲苯二异氰酸酯(TDI)、聚乙二醇(PEG-6000)、二羟甲基丙酸(DMPA)及三乙撑四胺(TEFA)等为原料,合成了温度、pH、及离子强度敏感性聚氨酯水凝胶(PUHG)。研究了PUHG溶胀率(SR)受温度(T)、pH、离子强度(I)、交联剂用量等因素的影响。结果表明PUHG的溶胀率在20~45℃的范围内随温度的升高而减小,45℃后不再变化;在酸性(pH4)溶液中收缩,在碱性(pH9)溶液中溶胀,表现出良好的pH值敏感性;在一定温度和pH下,随着离子强度的增加PUHG的溶胀率减小。水凝胶溶胀动力学研究表明,PUHG具有良好的溶胀-退胀可逆性。更多还原

【Abstract】 Polyurethane hydrogel, which exhibits pH、temperature and ionic intensity-sensitive, was prepared from toluene diisocyanate(TDI), polyethylene glycol(PEG-6000), dimet hylol propionic acid(DMPA) and triethylene tetramine(TEFA).The swelling ratio of the PU hydrogel(PUHG), which can act as a influence of pH、temperature、ionic intensity and crosslinking agent, was studied in detail . The result showed that the swelling ratio of PUHG decreased with the temperature increasing between 20 and 45℃; in alkaline medium(pH=9) , the swelling ratio of the PU hydrogel was more than that of In acid medium(pH=4); the swelling ratio of PU hydrogel decreased with ionic intensity increasing at a temperature and pH. The results of swelling dynamic indicated that PU hydrogel can change reversibly well at different pH and temperature. The PU hydrogel are suitable for use in biomedical controlled delivery of medicines.更多还原