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组织型谷氨酰胺转氨酶在肿瘤生物学中的作用
Tissue transglutaminase(tTG) in cancer biology
【摘要】 组织型谷氨酰胺转氨酶是一种多功能酶,不仅可以催化多种蛋白质形成交联分子稳定细胞外基质,而且可以调节肿瘤生长、细胞分化、细胞凋亡和细胞黏附。本文就该酶的一般特性及在肿瘤生物学中的作用进行综述。
【Abstract】 Tissue transglutaminase is a multifunctional enzyme which is involved in the regulation of cell growth,differentiation and apoptosis.Recently,a growing body of literature suggests that it be closely related to cancer and its role in cancer biology is briefly reviewed in this paper.
【关键词】 转谷氨酰胺酶;
肿瘤转移;
肿瘤发生;
细胞分化;
细胞外基质;
【Key words】 transglutaminase; neoplasm metastasis; tumorigenicity; cell differentiation; extracellular matrix;
【Key words】 transglutaminase; neoplasm metastasis; tumorigenicity; cell differentiation; extracellular matrix;
【基金】 国家自然科学基金(30470389);国家“973”计划(2002CB513105)资助
- 【文献出处】 军事医学科学院院刊 ,Bulletin of the Academy of Military Medical Sciences , 编辑部邮箱 ,2006年04期
- 【分类号】R730.231
- 【被引频次】3
- 【下载频次】206