【摘要】 目的探讨舍曲林合并舒必利治疗精神分裂症的疗效和安全性。方法将86例符合CCMD-3诊断标准的精神分裂症患者随机分为研究组与对照组,研究组给予舍曲林合并舒必利治疗,对照组服用利培酮,疗程8周,用PANSS、CGI、BPRS及TESS评定疗效和安全性。结果疗后8周舍曲林合并舒必利组总有效率为88．37%,维思通组总有效率69．77%,两组比较有显著性差异(P＜0．05)。两组治疗前后PANSS、BPRS评分均有明显下降(P＜0．05),两组间比较研究组两量表总分下降更明显,差异有显著性(P＜0．05),尤其PANSS中一般精神病理量表分、BPRS中缺乏活力因子分、焦虑抑郁因子分差异显著(P＜0．05)。结论舍曲林合并舒必利治疗精神分裂症阴性与阳性症状疗效可靠,不良反应小,大大提高患者的生活质量。更多还原

【Abstract】 Objective:To probe the efficiency and security of sertraline combined with sulpiride on treatment of schizophrenia.Methods:86 schizophrenia patients were divided into two groups randomly,43 of Sertraline combining Sulpiride group,43 of Risperidone group,the period of observation is 8 weeks,assessing efficiency and security of two groups before treatment and 1,2,4,6,8 weeks after treating by PANSS、CGI、BPRS and TESS scales.Results:All the subjects finished the trail.The total effective rates of two groups were 88.37% and 69.77%,respectively,there was a significant difference between two groups (P＜0.05).The total scores of PANSS and BPRS after and before treatment were significantly descent in each group (P＜0. 05).There was a significant difference between two groups (P＜0.05 ),especially the general psychopathology scale in PANSS,vital impulse defect factor and anxiety depressive factor in BPRS (P＜0.05 ).Conclusion: Sertraline combining Sulpiride is effective choice on treatment of positive and negative symptoms of Schizophrenia;the side effects were light,and it can improve the life quality of schizophrenic consumedly.更多还原