【摘要】 目的：调查广西黑衣壮族人群4个短串联重复序列(short tandem repeats,STR)基因座：D5S818、D7S820、D13S317、vWA的群体遗传分布资料,探讨7个民族间的遗传关系。方法：应用荧光标记STR基因扫描技术分析152名广西黑衣壮族无关个体。以遗传距离和系统发生树来分析7个民族间遗传关系。结果：4个STR基因座平均观察杂合度为0．7814；平均多态信息总量为0．7375；累积个体识别力达0．9928809,累积非父排除率达0．9928809。新疆乌孜别克族、新疆维吾尔族、甘肃裕固族、云南白族、广西黑衣壮族、浙江畲族聚为一群,东部蒙古族自成一群。结论：广西黑衣壮族的4个STR基因座属高度遗传多态性标记；新疆乌孜别克族和维吾尔族、广西黑衣壮族和浙江畲族遗传关系较近。更多还原

【Abstract】 Objective:To investigate the distribution of four short tandem repeats (STR) loci (D5S818,D7S820, D13S317,and vWA)in Heiyi Zhuang Ethnic in Guangxi autonomous region and to study the genetic relationship between 7 minorities.Methods:Totally 152 unrealated individulas were analyzed by STR genescanning marked by fluorescence.Genetic distance was computed and phylogenetic tree was constructed for studying the genetic rela- tionship between 7 minorities.Results:The average heterozygosity in the four STR loci was 0.781 4;the average polymorphism information content was 0.737 5;the accumulative discrimination power was 0.992 880 9,and the accumulative probability of paternity exclusion was 0.992 880 9.All 7 populations were clustered into 2 groups. Uzbek,Uigur,Yugu,Bai,She,and Heiyi Zhuang Ethnic of GuangXi were in the same group,and eastern Mon- golia alone was another group.Conclusion:The data obtained are highly polymorphisms.Genetic relationship be- tween Uzbek and Uigur,Heiyi Zhuang and She is closer.更多还原