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小鼠附植前胚在子宫内的迁移能力

MIGRATION CAPABILITY IN UTERI OF MOUSE PREIMPLANTATION EMBRYOS

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【作者】 李相运邸科前魏巍雍军

【Author】 LI Xiang-yun~(1*),Di Ke-qian~1,WEI Wei~2,YONG Jun~3 (1.College of Animal Science and Technology,Agricultural University of Hebei, Baoding 071001,China;2.College of Life Science,Peking University,Beijing 100871,China;3.Beijing Vitalriver Laboratory Animal Inc,Beijing 100012,China)

【机构】 河北农业大学动物科技学院北京大学生命科学学院北京维通达生物技术有限公司 保定071001保定071001北京100871北京100012

【摘要】 目的观察小鼠附植前胚在子宫内的迁移能力。方法将CD-1小鼠受精卵、2-细胞胚、桑椹胚、囊胚、四倍体胚、孤雌活化胚等6种胚共1 042枚单侧(右侧)移植CD-1假孕母鼠的输卵管或者子宫,观察移植胚在两侧子宫角内的附植情况。结果共得到45只妊娠鼠,在这45只鼠的右侧子宫角都有不同数目的着床胚,而仅在6只鼠的左侧子宫角发现了6枚着床胚。结论小鼠胚在子宫内的迁移能力非常有限,单侧移植的多个胚很少的机率迁移到另一侧子宫角内着床,不能进行胚均匀分布。

【Abstract】 Objective To study the migration capability of mouse preimplantation embryos in uteri.Methods Total(1?045) embryos from CD-1 mouse including fertilized oocytes,2-cell embryos,morula,blastocysts,tetraploid embryos and parthenogenetic embryos were transferred unilaterally(right uterus or oviduct) into pseudopregnant CD-1 recipient females. Results Forty-five pregnant recipients were obtained.Among 45 recipients,implanted embryos,the scope from 5 to 20,were found at right uterine horn in each pregnant recipient,but only 6 implanted embryos in left uterine horn of 6 pregnant recipients.Conclusion Mouse preimplantion embryos barely migrate and move in between two uterine horns,embryos transferred unilaterally also can not implante equaly in left and right uterine horns.

【关键词】 胚胎迁移子宫小鼠
【Key words】 EmbryoMigrationUteriMouse
【基金】 国家自然科学基金(30571336);河北农业大学校长基金资助
  • 【文献出处】 解剖学报 ,Acta Anatomica Sinica , 编辑部邮箱 ,2006年01期
  • 【分类号】R-332
  • 【被引频次】1
  • 【下载频次】92
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