【摘要】 目的探索FAK和PI3K在胃癌发生发展过程中的作用及相互关系。方法采用免疫组织化学Envision二步法对112例胃癌及76例正常胃粘膜组织的FAK和PI3K进行检测,并加以分析比较。结果胃癌组FAK、PI3K表达均明显高于正常胃粘膜组(分别为χ2=13.900,P<0.001;χ2=9.994,P<0.05);且随着癌浸润深度的加深(分别为χ2=9.367,P<0.05;χ2=7.896,P<0.05)和淋巴结转移的出现(分别为χ2=8.932,P<0.05;χ2=9.455,P<0.05)FAK和PI3K表达明显增强,且胃癌中PI3K与FAK表达呈明显正相关(r=0.258,P<0.01)。结论胃癌组织PI3K活化与FAK明显相关,两者在胃癌发生发展过程中起促进作用,有望成为胃癌治疗的新靶点。更多还原

【Abstract】 Objective To explore the expression of FAK and PI3K on gastric cancer and their relationship Methods Detecting FAK and PI3K of normal gastric mucosa and gastric carcinoma by immunohistochemistry EnVision method.Results The results Showed that the expression of FAK and PI3K of gastric carcinoma in-creased than that of normal gastric mucosa(χ2=13.900,P<0.001;χ2=9.994,P<0.05).Comparing with non-running muscular layer group the expression of FAK and PI3K enhanced obviously than that of running mus-cular layer group(χ2= 9.367,P< 0.05;χ2= 7.896,P< 0.05),and the results was semblable in lymphatic metastasis group contrasting with non-lymphatic metastasis group(χ2=8.932,P<0.05;χ2=9.455,P<0.05).FAK There is apositive correlationn between FAK and PI3K(r=0.258,P<0.01).Conclusion There has closely relationship with PI3K,they play a important role in carcinogenesis and development of gastric carcinoma and may become the treating target of gastric cancer.更多还原