节点文献

FAK PI3K在胃癌中的表达及相关性研究

The Expression of PI3k and FAK on Gastric Cancer and Their Relationship

  • 推荐 CAJ下载
  • PDF下载
  • 不支持迅雷等下载工具,请取消加速工具后下载。

【作者】 王舟王学春赵瑞花梁桂华王旭

【Author】 WANG Zhou,WANG Xuechun,ZHAO Ruihua,et al(Department of Pathology,Jining Medical College)

【机构】 济宁医学院病理学教研室济宁医学院病理学教研室平度市人民医院

【摘要】 目的探索FAK和PI3K在胃癌发生发展过程中的作用及相互关系。方法采用免疫组织化学Envision二步法对112例胃癌及76例正常胃粘膜组织的FAK和PI3K进行检测,并加以分析比较。结果胃癌组FAK、PI3K表达均明显高于正常胃粘膜组(分别为χ2=13.900,P<0.001;χ2=9.994,P<0.05);且随着癌浸润深度的加深(分别为χ2=9.367,P<0.05;χ2=7.896,P<0.05)和淋巴结转移的出现(分别为χ2=8.932,P<0.05;χ2=9.455,P<0.05)FAK和PI3K表达明显增强,且胃癌中PI3K与FAK表达呈明显正相关(r=0.258,P<0.01)。结论胃癌组织PI3K活化与FAK明显相关,两者在胃癌发生发展过程中起促进作用,有望成为胃癌治疗的新靶点。

【Abstract】 Objective To explore the expression of FAK and PI3K on gastric cancer and their relationship Methods Detecting FAK and PI3K of normal gastric mucosa and gastric carcinoma by immunohistochemistry EnVision method.Results The results Showed that the expression of FAK and PI3K of gastric carcinoma in-creased than that of normal gastric mucosa(χ2=13.900,P<0.001;χ2=9.994,P<0.05).Comparing with non-running muscular layer group the expression of FAK and PI3K enhanced obviously than that of running mus-cular layer group(χ2= 9.367,P< 0.05;χ2= 7.896,P< 0.05),and the results was semblable in lymphatic metastasis group contrasting with non-lymphatic metastasis group(χ2=8.932,P<0.05;χ2=9.455,P<0.05).FAK There is apositive correlationn between FAK and PI3K(r=0.258,P<0.01).Conclusion There has closely relationship with PI3K,they play a important role in carcinogenesis and development of gastric carcinoma and may become the treating target of gastric cancer.

【关键词】 磷脂酰肌醇3-激酶焦点粘附激酶胃癌
【Key words】 PI3KFAKGastric cancer
  • 【文献出处】 济宁医学院学报 ,Journal of Jining Medical College , 编辑部邮箱 ,2006年04期
  • 【分类号】R735.2
  • 【被引频次】3
  • 【下载频次】183
节点文献中: 

本文链接的文献网络图示:

本文的引文网络