【摘要】 采用离子液体四氟硼酸正丁基吡啶盐([bpy]BF4)作催化剂和反应介质,芳香醛、乙酰乙酸乙酯、尿素进行三组分B iginelli缩合,制备了3,4-二氢嘧啶-2-酮衍生物.结果表明,反应时间短、操作简便、产率60%~70%、不需使用有机溶剂,离子液体可重复使用,对环境友好.更多还原

【Abstract】 Dihydropyrimidiones and their derivatives were synthesized by the Biginelli three component condensation of aromatic aldehydes,ethyl acetoacetate ester and urea（using） room temperature ionic liquid n-butyl pyridinium tetrafluoroborate BF₄ as a（catalyst） and medium.The results showed the protocol has the advantages such as short reaction time,simple procedures,moderate yields,the ionic liquid reusability and benign to environmental without using organic solvent.更多还原