【摘要】 研究了超临界CO2提取青蒿素的工艺,考察了粒度、压力、温度、时间、CO2流量等影响因素.以萃取率为目标,综合考虑产品收率,优化了超临界萃取工艺条件,得到较佳的操作条件:萃取压力20 MPa,萃取温度50℃,每千克原料CO2质量流量1 kg/h,分离器Ⅰ的温度为60℃,压力为14 MPa.在优化条件下萃取4 h,萃取率达到95%以上,萃取物纯度在15%以上.更多还原

【Abstract】 The supercritical fluid extraction（SFE） of artemisinin was studied using ground Artemisia annua L.as raw material and CO₂ as solvent.The effect of operation conditions on the extraction yield was analyzed in a series of experiments at temperatures between 313 and 333 K and pressures between 15.2 and 29.7 MPa and humidity of raw material between 2.5% and（11.3）%.Furthermore,the effect of CO₂ flow rate and particle size of raw material was studied in the range of 0.162 to 1.968 kg/h and 40 to 80 meshes.The optimum conditions were pressure of 20 MPa,temperature of 323 K,a solvent ratio of 1 kg of CO₂ per kg of raw material,and particle size of 60⁸0 mesh.For high yield of artemisinin,the operating conditions of the separatorⅠ were that the temperature was 323 K and the pressure was 20 MPa.In these conditions,the extraction yield was more than 95% and the purity of artemisinin of the extract was 15% for extraction time of 4 h.更多还原