【摘要】 L-组氨酸在醛的催化下,可在羧酸溶剂中发生消旋.L-组氨酸在乙酸溶剂中消旋最快,其合适的催化剂应是水杨醛;L-组氨酸以(R)-酒石酸为拆分试剂,在乙酸溶剂中,在水杨醛存在时进行不对称转换,合成了D-组氨酸的酒石酸盐,经处理得到D-组氨酸.在最佳反应条件下,总收率达94.85%,光学纯度>99.5%.更多还原

【Abstract】 L-Histidine(LHis) could be racemized in carboxylic acids used as solvents in presence of catalyst such as salicylaldehyde.The rate of racemization of LHis was the most rapid in acetic acid.the suitable catalyst is salicylaldehyde.An asymmetric transformation from LHis to DHis through formation of salt with(R)tartaric acid was achieved by using salicylaldehyde as a catalyst for epimerization in acetic acid,and DHiso(R)TA salt was obtained.Treatment of the salt gave DHis with optical purity larger than 99.5% in 94.85% yield based on the starting material under the optimistic conditions.更多还原