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人参皂苷Rg₃（R）,Rg₃（S）,Rg₅/Rk₁对乙醇致小鼠记忆阻碍改善作用的影响

Effects of Ginsenosides Rg₃（R）,Rg₃（S） and Rg₅/Rk₁ on Memory Improvement of Ethanol Treated Mice

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【Author】 ZHANG Jing~1,WANG Shi-rong~2,CHEN Quan-cheng~1,P.H.Long~3,J.S.Kang~3(1.College of Chinese Medicinal Material,Jilin Agricultural University,Changchun 130118,China;(2.Changchun) Gaipu Manufacturer of Pharmaceuticals Co.,Ltd.,Changchun 130033,China;(3.College) of Pharmacy,Chungnam National University,Daejeon 305-764,Korea)

【机构】吉林农业大学中药材学院；长春盖普药业有限公司；韩国忠南大学药学院；韩国忠南大学药学院长春130118；长春130033；长春130118；大田305-764韩国；

【摘要】采用被动回避穿越法研究了人参皂苷Rg3(R),Rg3(S)和Rg5/Rk1(1∶1)对乙醇致小鼠记忆阻碍改善作用的影响。结果表明:灌服人参皂苷Rg3(R),Rg3(S)和Rg5/Rk110 mg/kg后,显著延长了小鼠避暗的潜伏期,尤其以人参皂苷Rg5/Rk1作用最为显著,Rg5/Rk1处理组的潜伏期是对照组的2.97倍,Rg3(R),Rg3(S)分别为对照组的2.35和2.53倍,差异极显著(P<0.01)。说明这些化合物具有改善乙醇致小鼠的记忆障碍的能力。更多还原

【Abstract】 Effects of administration of ginsenosides Rg₃（R）,Rg₃（S） and Rg₅/Rk₁（1∶1）were examined on the impairment of acquisition induced by single oral administration of ethanol in step-through test.The result shows that the inhibitory effect of ethanol on the impairment of acquisition was significantly reduced by administration of ginsenosides Rg₃（R）,Rg₃（S） and Rg₅/Rk₁（1∶1）.They can significantly prolong latency of the mice,especially Rg₅/Rk₁.The latency of Rg₅/Rk₁,Rg₃（R） and Rg₃（S） groups is longer than that of control group,2.97,2.35 and 2.53 times respectively.The results suggest that those compounds have the ability to improve the acquisition of ethanol-treated mice.更多还原