【摘要】 目的比较西酞普兰与米氮平治疗老年抑郁症的疗效和不良反应。方法将50例老年抑郁症患者随机分为西酞普兰组和米氮平组。分别给予西酞普兰和米氮平治疗,疗程8周,采用汉密尔顿抑郁量表(HAMD)及副反应量表(TESS)评定疗效和副反应。结果西酞普兰组和米氮平组显效率分别为84.0%和80.0%,二者疗效相当(P>0.05)。HAMD评分西酞普兰组第2周末显著下降,而米氮平组治疗第1周末即显著下降,副反应方面,西酞普兰组以口干、恶心、出汗增多、睡眠时间缩短为主,米氮平组则以嗜睡、眩晕、头疼为主。结论西酞普兰和米氮平均为治疗老年抑郁症的安全有效的药物。更多还原

【Abstract】 Objective To compare the efficacy and safety of citalopram and mirtazapine in the treatment of senile depressive patients. Methods Fifty elderly patients with depression were randomly divided into citalopram group or mirtazapine group for 8 weeks respectively. The efficacy and side effects were evaluated by Hamilton depressive scale(HAMD)and treatment emergent symptom scale (TESS). Results The effective rates of citalopram and mirtazapine were 84.0% and 80.0% respectively, there was no significant difference between two groups (P>0.05). After eight weeks of trent, the scores of HAMD were significantly lower than before treatment in both groups. The scores of HAMD decreased significantly at the end of the second week in citalopram group, but did at the end of the first week in mirtazapine group. The inncidence of dry mouth, nausea, more sweat, shorten sleeping in citalopram group than in mirtazapine group, while the incidence of somnolence、dizzinese、headache in mirtazapine group than in citalopram group. Conclusion Citalopram and mirtazapine are safe and effective drug in the treatment of senile depression.更多还原