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富马酸氯马斯汀凝胶的研制与质量控制
Preparation and Quality Control of Clemastine Fumarate Gel
【摘要】 目的研制富马酸氯马斯汀凝胶剂,建立质量控制方法。方法用卡波姆-940为凝胶基质,用分光光度法测定含量,考察制剂的稳定性。结果该制剂均匀性、分散性好;含量测定平均回收率为99.78%,RSD为0.81%(n=3)。结论该制剂制备工艺简单,质量可控。
【Abstract】 Aim To study the prescription and preparation of Clemastine fumarate gel,and set up the method of control quality.Methods Carbopol-940 was used as base.The content was determined by spectrophotometry.The stability of Clemastine fumarate gel loas also investigated.Results The preparation was well-distributed.The average recovery of the Clemastine fumarate was 99.78%, RSD =0.81%( n =3).Conclusion The preparation process is simple and the quality can be controlled.
- 【文献出处】 解放军药学学报 ,Pharmaceutical Journal of Chinese People’s Liberation Army , 编辑部邮箱 ,2006年01期
- 【分类号】R943
- 【被引频次】4
- 【下载频次】95