【摘要】 目的观察绝经后妇女长期用小剂量性激素替代疗法(HRT)后,其血清炎性因子C反应蛋白(CRP)及同型半胱氨酸(Hcy)水平的改变。方法选择北京协和医院的141例绝经后女医护人员,其中63例经小剂量性激素替代疗法5~32年,作为HRT组,78例年龄匹配的未经性激素替代疗法者,作为对照组,分别取血测血清雌二醇(E2)、促卵泡激素(FSH)、CRP和Hcy水平。结果HRT组E2水平(中位数,四分位间距;33.8 ng/L,30.9)明显高于对照组的(21.3 ng/L,33.2)(P<0.05),然而,两组的血清FSH[(54.4±18.9)U/L比较(60.4±24.4)U/L]、Hcy[(10.6±2.5)μmol/L比较(11.4±4.3)μmol/L]和CRP(中位数,四分位数间距;12.6 mg/L,11.0比较12.2 mg/L,9.0)水平无明显差异,CRP及Hcy的血清浓度分别与血清E2及FSH水平均无明显相关关系。结论绝经后妇女经长期小剂量性激素替代治疗,未见与发生心血管疾病密切相关的因子CRP及Hcy水平升高,显示绝经后妇女长期应用小剂量HRT可能是安全的。更多还原

【Abstract】 Objective To investigate the effects of long-term,low-dose hormone replacement therapy（HRT） on serum level of creactive protein（CRP） and homocysteine（Hcy） in postmenopausal women.Methods A total of 141 postmenopausal women were selected from medical staff of the Peking Union Medical College Hospital.Of these,63 subjects have been treated with low-dose sex hormone for over 5 years（HRT group）,78 subjects have never received hormone replacement therapy as control group.The serum levels of CRP and Hcy in two groups were evaluated.Results The serum level of estradiol（E₂） in HRT group was significant higher than that in control group（median,inter-quartile range;33.8 ng/L,30.9 vs 21.3 ng/L,33.2）（P<0.05）.The serum level of follicle-stimulating hormone（FSH）[（54.4±18.9） U/L vs（60.4±24.4） U/L],c-reactive protein（median,inter-quartile range;1.26 mg/dl,1.10 vs 1.22 mg/dl,0.90） and homocysteine [（10.6±2.5）μmol/L vs（11.4±4.3）μmol/L] showed no significantdifference between HRT group and control group（P>0.05）.There was no correlation between the serum level of CRP,Hcy and the plasma levels of E₂ and FSH respectively.Conclusion Long-term and low-dose HRT does not increase the serum level of CRP and Hcy in postmenopausal women.更多还原