【摘要】 目的探讨在脑出血的病理过程中大量释放具有生物活性的血管活性肽-内皮素与脑出血之间的关系,及其对脑出血周围脑组织缺血损害的病理学意义。方法实验动物为Wistar大鼠,随机分为两组脑出血组24只,用大鼠自体静脉血制造脑出血模型;对照组23只。分别于脑出血后4h,8h,12h,24h,72h,及7d取血,进行选定指标的外周血测定。按照上述时间对于不同实验组动物的外周血进行血清内皮素测定。取8h的血清测定值,两组测定值比较。所有数据均以均值±标准差表示,应用专用统计学软件进行t检验。结果在脑出血的6个时间中,4项实验指标均呈现渐升渐降的变化特征,且都在8h血样中达到高峰值,两组相比有统计学意义。结论血浆内皮素在脑出血的早期8h呈现高峰值,提示我们脑出血后脑内ET过度表达可能是血肿周围存在水肿和继发缺血的主要因素之一。ET也可以作为估计预后的一种指标广泛应用于临床。更多还原

【Abstract】 Objective To investigate the relationship between the endothelin and intracerebral hemorrhage and the pathological effect on the brain tissue perihematoma.Methods Wistar mice were randomly divided two groups: hemorrhage group(n=24) and control (n=23). The intracerebral hemorrhage model were made by autoallergic venous blood. The level of serum endothelion were examined 4h,8h,12h,24h,72h,and 7d after hemorrhage. Results the endothelin level achieved the peak at 8h after hemorrhage. there were significant difference between two groups at this point.Conclusions the results suggest that the overexpression of endothelion could be the one of the main factors causing the edema and second ischemia .The endothelin could be used to estimate the prognosis.更多还原