【摘要】 目的探讨肝细胞生长因子(hepatocyte growth factor,HGF)及其受体C-M et和血管内皮生长因子(vascu lar ep ithelial growth factor,VEGF)在卵巢癌中表达的意义。方法应用免疫组织化学方法检测35例人卵巢癌组织标本中HGF、C-M et和VEGF蛋白的表达情况。结果HGF、C-M et和VEGF蛋白在卵巢癌组织中的表达明显高于卵巢良性肿瘤组织(P<0.05),阳性表达率随癌的组织学分级,临床分期增加而增高。结论卵巢癌组织中HGF、C-M et和VEGF蛋白的表达,可能与患者的预后密切相关。更多还原

【Abstract】 Objective To study the expression of HGF、C-Met and VEGF protein in the ovarian cancer tissue and its prognostic value.Methods The expression of HGF、C-Met and VEGF protein was studied with immunohistochemical S-P method.Results In ovarian cancer tissue,the positive expression of HGF、C-Met and VEGF protein was much higher than those of ovarian benign tumor(P<0.05).The expression of HGF、C-Met and VEGF protein was positively correlated with histological differentiations,PTNM classification and lymph node metastasis.Conclusion High activities of HGF、C-Met and VEGF protein enhances the tumor growth and the capacity to invade locally and metastasize.HGF、C-Met and VEGF protein may act as prognostic markers for patients with ovarian cancer after operation.更多还原