【摘要】 目的探讨狼疮肾炎患者抗肾小球基底膜抗体(anti-GBM)与抗双链DNA抗体(anti-ds DNA)和抗核小体抗体(anti-NuA)的关系。方法反馈分析28例anti-GBM阳性的狼疮肾炎患者致肾炎抗体间的关系。结果28例anti-GBM阳性的狼疮性肾炎患者有13例anti-ds DNA阳性和17例anti-NuA阳性。并且,血清anti-GBM的水平与anti-ds DNA和/或anti-NuA水平一致。结论anti-GBM与anti-ds DNA和anti-NuA呈正相关;联合检测这些肾炎抗体对疾病的治疗和预后判断有指导意义。更多还原

【Abstract】 Objective To establish whether the anti-glomerular basement membrane antibodies(anti-GBM)correlate with anti-double stranded DNA antibody(anti-dsDNA) and anti-nucleosome antibodies(anti-NuA) in patients with lupus nephritis(LN).Methods 28 LN patients with anti-GBM were enrolled into the retrospective study.LN patient sera were previously tested for anti-GBM,antidsDNA and anti-NuA.Results At hospitalization,significant differences of serum anti-GBM levels were found in the LN patients with the presence and absence of anti-dsDNA(13 cases positive) and anti-NuA(17 cases positive).Furthermore,serum anti-GBM levels were highly correlated with the presence of both antidsDNA and anti-NuA.Conclusion Anti-GBM,together with the additional nephritogenic potential of anti-dsDNA and anti-NuA,may play an essential role in the pathogenesis of the anti-GBM disease in LN.更多还原