【摘要】 目的研究人转化生长因子β1(TGF-β1)与冠心病临床关系。方法用酶联免疫吸附(ELISA)法测定CHD患者和对照组血清中TGF-β1含量,CHD组结合症状分为ACS、SAP亚组,结合冠脉造影结果分为单支病变、双支病变、三支病变组,根据冠脉粥样硬化严重程度积分。结果TGF-β1水平CHD患者低于对照组,ACS组低于SAP组,三支病变组低于单支病变组,TGF-β1水平和冠状动脉狭窄程度呈负相关。结论TGF-β1利于稳定冠心病症状,减少ACS发生,可以抑制冠脉粥样硬化斑块形成。更多还原

【Abstract】 Objective To investigate the clinical relationship between transforming growth factor-β₁（TGF-β₁）and coronary heart disease（CHD）.Methods The serum TGF-β₁ were measured in 65 patients with CHD and 19 control subjects by ELISA method.We divided the CHD patients into two groups: 41 with acute coronary syndrome（ACS） and 24 with stable angina pectoris（SAP）.All subjects undergone coronary angiography（CAG）.Results The level of serum TGF-β₁ was significantly lower in CHD patients than that in control group（P<0.05）.ACS group showed lower level TGF-β₁ than that of SAP group（P<0.05）.The TGF-β₁ level was lower in patients with three disease coronary artery compared with that in patients with single disease coronary artery（P<0.05）.The TGF-β₁ level showed an inverse correlation with scores of coronary artery lesion（r=-0.4839,P<0.01）.Conclusion TGF-β₁ was related to the severity of symptom and plaque in CHD patients.TGF-β₁ showed protective effect in CHD.更多还原