【摘要】 目的观察比索洛尔治疗原发性高血压(EH)时对纤溶活性、内皮素(ET)、一氧化氮(NO)、降钙素基因相关肽(CGRP)的影响。方法42例健康体检者作为正常对照组,66例EH患者用比索洛尔治疗8周,观察用药前后血组织型纤溶酶原激活物(t-PA)及其抑制物(PAI)活性,ET、NO、CGRP浓度的变化。结果EH患者t-PA活性、CGRP和NO浓度明显低于正常对照组(P<0.01),而PA I活性、ET浓度明显高于正常对照组(P<0.01),比索洛尔治疗后,血t-PA活性、NO、CGRP浓度均较治疗前显著升高(P<0.01),血ET浓度显著下降(P<0.01)。结论EH患者纤溶活性和内皮功能异常,比索洛尔可改善EH患者纤溶活性和内皮功能。更多还原

【Abstract】 Objective To investigate effects of bisoprolol on fibrinolytic activity,endothelin(ET),nitric oxide(NO) and calaitonin gene related peptide(CGRP) in patients with essential hypertension.Methods 42 healths were assigned as normal control group,66 patients with essential hypertension were treated with bisoprolol for 8 weeks,plasma activity of tissue-type plasminogen activator(t-PA),plasminogen activator inhibitor(PAI) and plasma concentration of ET,NO and CGRP were measured before and 8 weeks after treatment.Results Plasma activity of t-PA and plasma concentration of NO,CGRP in patients with essential hypertension were significantly reduced than those in normal control group(P<0.01),plasma activity of PAI and plasma concentration of ET in patients with essential hypertension were remarkly higher than those in normal control group(P<0.01).After treatment,plasma activity of t-PA and plasma concentration of NO,CGRP were significantly elevated(P<0.01),plasma activity of PAI and plasma concentration of ET were remarkly decreased(P<(0.01)).Conclusion The plasma activity of t-PA,PAI and plasma concentration of ET,NO,CGRP are abnormal in patients with essential hypertension.The bisoprolol treatment can improve fibrinolytic activity and endothelial function in patients with essential hypertension.更多还原