【摘要】 目的观察单甘酯对血栓形成的影响。方法采用动静脉旁路血栓形成方法观察血栓形成并称重。颈总动脉血栓采用电刺激大鼠颈总动脉方法。小鼠肠系膜血管微血栓采用激光照射。肺栓塞采用小鼠尾静脉注射花生四烯酸。测定大鼠血浆纤维蛋白原含量。结果单甘酯25,50 mg.kg-1能够明显减轻动静脉旁路内丝线上血栓重量;单甘酯25,12.5 mg.kg-1能明显延长血管阻塞时间;单甘酯35.7和71.4 mg.kg-1明显延迟小鼠肠系膜血管微血栓出现时间。单甘酯40,80 mg.kg-1能明显降低花生四烯酸所致的小鼠死亡,单甘酯25,50和100 mg.kg-1显著降低大鼠血浆纤维蛋白含量。结论单甘酯具有明显的抗血栓形成作用。更多还原

【Abstract】 Objective To investigate the effects of glycol mannate sulfate（GMS） on thrombogenesis.Methods The thrombogenesis was observed by carotid artery and cervical vein bypass and the thrombus was weighted.Thrombogenesis in common carotid artery was induced by electric stimulation.Mice mesentery microthrombus formation was induced by laser.Pulmonary thromboembolism was induced by injection of arachidonic acid.Plasma fibrinogen of rats was measured.Results GMS 25,50 mg·kg^-1 could decrease the weight of thrombus cohered on suture silk significantly;25,12.5 mg·kg^-1 of GMS could prolong the obstruction time;GMS 35.7,71.4 mg·kg^-1 could delay the formation of mice mesentery microthrombus;GMS 40,80 mg·kg^-1 could decrease the mortality induced by arachidonic acid injection.At the dosages of 25,50 and 100 mg·kg^-1GMS could decrease the fibrinogen in plasma.Conclusion GMS could inhibit the thrombogenesis significantly.更多还原