【摘要】 目的:评价五酯胶囊、水飞蓟素对抗结核药物所致肝损害的预防和治疗效果。方法:112例住院HB-sAg(+)初治浸润型肺结核随机分为两组,均以2HRZE(S)/4HR方案抗结核治疗,治疗组于强化期加用五酯胶囊、水飞蓟素(西利宾胺或利加隆)。结果:治疗组47例发生可逆性中度转氨酶升高7例(14.9%);对照组65例,发生可逆性中度转氨酶升高25例(38.5%),两组差异显著(P<0.05)。同时观察HBsAg(-)住院初治浸润型肺结核102例,发生可逆性中度转氨酶升高9例(8.8%)。结论:HBsAg(+)病例接受抗结核治疗易发生药物性肝损害,五酯胶囊、水飞蓟素只对部分药物性肝损害有预防和治疗作用,而对药物过敏反应在抗结核药所致药物性肝损害中起一定作用。更多还原

【Abstract】 Objective:To evaluate the efficacy of Wuzhicapsules and Silymarin of drug induced hepatic toxicity.Methods:112 hospitalized HBsAg positive patients with pulmonary tuberculosis were randomized to wuzhicapsules and silymarin of control group in addition to 2HRZE/4HR therapy.Results:Middle level reversible serum aspartate transam inase elevation(14.9% vs 38.5% P<0.05)occurred more commonly in the 65 patients randomized to the control group.There exists statistically significant difference between the two groups.Meanwhile 102 HBsAg negative patients with pulmonary tuberculosis were observed and only 8.8% of them occurred middle level reversible serum aspartate transaminase elevation during antituberculous therapy.Conclusion:Medicamentous liver injury may occurred more commonly in HBsAg positive patients after antituberculous therapy.wuzhicapsules and silymarin can only prevent and cure part of them.Drug anaphylactic reaction may play a role in pathogenesis of hepatic damage.更多还原