【摘要】 目的观察和分析阿仑膦酸钠(ALN)对维甲酸所致实验性骨质疏松大鼠的防治作用。方法观察ALN(1.8、3.6 mg.kg-1.d-1)对维甲酸所致实验性骨质疏松大鼠股骨头和股骨干部位的骨矿密度、股骨头的钙磷含量以及强迫游泳时间的影响。结果与模型对照组相比,ALN可明显增加维甲酸所致实验性骨质疏松大鼠股骨头和股骨干部位的骨矿密度(P<0.05,P<0.01),钙、磷含量(P<0.05)及强迫游泳时间(P<0.01)。结论ALN可使维甲酸所致实验性骨质疏松大鼠骨钙、磷含量的提高,骨矿密度的增加,运动能力的提高,有明显的防治骨质疏松作用。更多还原

【Abstract】 OBJECTIVE To evaluate and analyze the preventive and therapeutic effects of Alendronate（ALN） on osteoporosis（OP） in rats induced by retinoic acid.METHODS The studies were carried out to determine the effects of ALN(1.8、3.6 mg·kg^-1·d^-1) on bone mineral density of femoral shaft and femoral head,calcium and phosphorus contents of femoral head and duration of immobility in the forced swim test in rats with osteoporosis induced by retinoic acid.RESULTS ALN significantly antagonized the decreases in bone mineral density（P<0.05 or P<0.01）,calcium content（P<0.05）,phosphorus content（P<0.05）,and duration of immobility（P<0.01） in rats with osteoporosis induced by retinoic acid.CONCLUSION ALN could increase contents of calcium and phosphorus,decrease bone mineral density loss,improve ability of immobility in rats with osteoporosis induced by retinoic acid.These results suggest that ALN has a distinct preventive and therapeutic effect on osteoporosis in rats induced by retinoic acid.更多还原