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6-(4-取代苯基)-5-甲基-4,5二氢-3(2H)哒嗪酮类化合物的合成及其抑制血小板聚集作用

Synthesis and platelet aggregation inhibition activity of analogues 6-4-(substituted phenyl)-5-methyl-4,5-dihydro-3(2H)-pyridazinones

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【Author】 QIN Jun~1,WANG Xiang-zhi~1,LIU Yi-min~1,XIAO Xiang~1,LIU Hai-hong~1,CHENG Xiao-ling~2(1.Department of Chemistry,Third Military Medical University,Chongqing 400038,China;2.Department of Transfusion,Southwest Hospital,Chongqing 400038,China)

【机构】第三军医大学化学教研室；第三军医大学西南医院输血科重庆；重庆；重庆400038；

【Abstract】 The 6-4(substituted phenyl)-5-methyl-4,5-dihydro-3(2H)-Pyridazinones were designed and synthesized for searching more potent platelet aggregation inhibitor.A series of reactions,such as Friedel-Crafts acylation reaction,cyanidation,hydrolysis,cyclation were used to synthesize the title compounds.The structures of all title compounds synthesized were confirmed by ~1H NMR,MS,IR,and element analysis.Results of pharmacological test showed that four compounds synthesized have the potent inhibition activities against the human platelet aggregation induced by adenosine diphosphate(ADP)in vitro.更多还原

【关键词】哒嗪酮；化学合成；血小板聚集；
【Key words】 pyridazinone； chemical synthesis； platelet aggregation；

【文献出处】化学研究与应用 ,Chemical Research and Application , 编辑部邮箱 ,2006年09期

【分类号】R914;R96
【被引频次】5
【下载频次】98

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