【摘要】 用司盘(Span)系列非离子表面活性剂和胆固醇(CHOL)通过真空旋转一超声波法制备了头孢噻肟钠囊泡,研究了包封条件对包封率的影响及包封后的药物在体外的模拟释放,考察了头孢噻肟钠囊泡的形态和构造。实验表明:Span20与CHOL摩尔比为2∶1,50°C超声30m in,对1.00g/L的注射用头孢噻肟钠的包封率可达55%以上,而且在模拟肠流体和模拟胃流体中均有缓释作用。更多还原

【Abstract】 Cefotaxime sodium was encapsulated in niosomes formed by non-ionic surfactant Span with Choles via a evaporation-sonication method.To obtain a higher encapsulation efficiency,factors including the structure of the surfactant,sonicaton,content of the drug and Cholesterol were investigated and optimized.Furthermore,the release behavior of Cefotaxime Sodium encapsulated in the noisome in simulated gastric and intestinal fluid was studied.The morphology and size of the niosomes were visualized by transmission electron microscopy.The results show that the entrapment efficiency of the niosomes for cefotaxime sodium could be as high as 55% under the following experimental conditions:drug concentration 1.00g/L,molar ratio of Span20 to Cholestero 2∶1 and sonication for 30min at 50°C.The release profiles in simulated gastric and intestinal fluid showed a controlled release tendency to some extent.更多还原