【摘要】 以乙二胺,芳香醛和相应的卤代物为原料合成了N-茄呢基-N,N′-二(3,4-二甲氧基苄基)乙二胺(SBD-乙二胺)及三个新的衍生物.对L1210和CHO细胞初步的体外活性测试表明在SBD-乙二胺的仲氮上引入第四个取代基后,生成的衍生物对所测细胞的抑制活性提高,但对长春新碱的增效作用减弱.更多还原

【Abstract】 N-Solanesyl-N,N′-bis(3,4-dimethoxybenzyl)ethylenediamine(SDB-ethylenediamine) and its three close analogues were synthesized using ethylenediamine,corresponding aromatic aldehydes and halides.The preliminary in vitro tests revealed that after the fourth group was introduced on the secondary nitrogen of SDB-ethylenediamine,the cytotoxicity of resulted analogues was increased and the synergism with vincristine was reduced for both L1210 and CHO cells.更多还原