【摘要】 N-叔丁基苯基呋喃甲酰肼是具有良好生物活性的含呋喃环双酰肼类昆虫生长调节剂(IGRs)的重要中间体,可由酰氯与叔丁基肼发生亲核反应制得。通过反应条件探索,获得了同时制备N1-叔丁基苯基呋喃甲酰肼和N2-叔丁基苯基呋喃甲酰肼的合成方法,并用此法制备了10个未见报道的新化合物,其结构通过1HNMR、IR、MS及元素分析确证。本文还通过计算化学方法对其反应机理及在不同条件下所生成异构体的现象进行了初步探讨。更多还原

【Abstract】 N-tert-butylphenylfuran acylhydrazines are the most important intermediates of diacylhydrzaines containing furan with high bioactivity against insects. Ten new titled compounds were synthesized by the nucleophilic reaction of acylchloride and tert-butyl hydrazine and identified by ~1H NMR, IR, MS and elemental analysis. The reaction mechanisms and isomerization were also discussed.更多还原