【摘要】 目的探讨牙周感染对2型糖尿病患者血清C反应蛋白(CRP)水平的影响。方法选择伴重度慢性牙周炎的2型糖尿病患者32例为试验组,以年龄(±3岁)、性别、体重指数(±1kg/m2)配比单纯2型糖尿病患者32例为对照组。采用超敏CRP酶联免疫法测定所有患者的血清CRP水平。结果试验组患者血清CRP水平平均为3.07mg/L,对照组为1.78mg/L,试验组高于对照组(P<0.05);试验组血清CRP≥3.0mg/L的患者占53.13%,对照组为28.13%,试验组高于对照组(P<0.05)。结论牙周感染可升高2型糖尿病患者血清CRP水平,这种炎性因子的升高可能会加重胰岛素抵抗,增加2型糖尿病患者大血管并发症的危险性。更多还原

【Abstract】 Objective To investigate the effect of periodontal infection on circulating C-reactive protein(CRP) in type 2 diabetes patients. Methods 32 diabetes patients with advanced periodontitis participated in this study. They were compared to a group of 32 diabetes patients without periodontal disease, who were mathed with regard to age(±3 years), gender and body mass index(±1 kg/m2). The concentration of CRP on circulation was measured by ELISA.Results Significant difference was found in the level of CRP and the percentage of subjects with elevated CRP levels≥3 mg/L on circulation between the two groups(P<0.05). Conclusion Periodontal infection results in highercirculating CRP in type 2 diabetes patients. This elevated inflammatory factor may exacerbate insulin resistance and increase the risk for great vessels complications of diabetes mellitus.更多还原