【摘要】 超临界反溶剂过程(SAS)是近年来提出的一种制备纳微米粉体的新方法。通过一套超临界反溶剂过程间歇式实验装置,以灰黄霉素、丙酮和二氧化碳系统为研究对象,实验研究了SAS过程参数对制备的微粒形态及其尺寸的影响。当操作条件为10 MPa,40℃,溶液浓度13.3 mg/mL和溶液流速1.5 mL/min时,制备了较为理想的灰黄霉素微粒,粒径分布均匀、形状基本呈球状;当8 MPa,42℃,溶液浓度15 mg/mL和溶液流速4.0 mL/min时,微粒粒径分布比较均一、主要呈细小针状。研究结果表明:采用丙酮作为有机溶剂,可制备出不同大小和形态的灰黄霉素超细微粒。这为改变灰黄霉素传统制剂做了前期准备工作,为制成可持缓释药物提供了可能性。更多还原

【Abstract】 Supercritical anti-solvent（SAS） process was proposed recently as a new technique to produce micro-and nano-particles.The effects of the SAS process parameters on particle morphology and its size were evaluated in the Griseofulvin-acetone-CO₂ system by semi-continuous supercritical anti-solvent precipitation apparatus.Uniform and spherical griseofulvin microparticles were observed at（10 MPa）,40 ℃,griseofulvin concentration in acetone of 13.3 mg/mL,the solution flow-rate of（1.5 mL/min）.Most of griseofulvin microparticles were uniform and needlelike at 8 MPa,42℃,（griseofulvin） concentration in acetone of 15 mg/mL,the solution flow-rate of 4.0 mL/min.（Experimental） results showed that griseofulvin microparticles of different sizes and morphologies could be obtained through SAS process when acetone was used as organic solvent.This method would be a preparative process for griseofulvin precipitation.It would make produce the sustained-release drug possible.更多还原