【摘要】 制备了新的Aβ斑块显像剂99Tcm-酰胺基氨基二硫醇(MAMA)-4-氨基-4′-二甲氨基联苯(DMABP),并研究了其在正常小鼠体内的生物分布。实验结果表明,99Tcm-MAMA-DMABP具有较高的初始脑摄取,较快的正常脑组织清除,尾静脉注射后2 min的脑摄取达0.88%/g,2 min与60 min的脑摄取率比值为2.8。更多还原

【Abstract】 Alzheimer’s disease（AD） is a neurodegenerative disease of the brain.Radioactive imaging agents for β-amyloid plaques in the brain will be useful in early noninvasive diagnosis and monitoring the progression of the disease.A new imaging agent for β-amyloid plaques,⁹⁹Tc^m-MAMA-DMABP was prepared,and its biodistribution in normal mice was studied.The results indicate that ⁹⁹Tc^m-MAMA-DMABP has fairly high initial brain uptake and fast brain clearance in normal mice.Brain uptake is 0.88%/g at 2 min post i.v.injection.Brain uptake ratio（2 min/60 min） is 2.8.更多还原