【摘要】 以人类肝癌细胞SMMC-7721和正常肝细胞L02为研究对象,以这两种细胞0.3 Gy时超敏感性的存活数据为基础,从理论上探讨了γ射线照射时,用超分次技术治疗肝癌的可能性。经过计算发现:如果目标肿瘤和周围的正常组织超敏感性的存活差异提高到3%,即可利用超分次技术对肿瘤进行治疗。应用超分次进行分次照射时,照射的结果与分次的间隔时间有关。对这一现象的机理进行了一定的探讨,发现时间间隔与细胞G2期的长短可能存在一定的相关性。更多还原

【Abstract】 Based on the survival data of human hepatoma SMMC-7721 and normal liver L02 cells irradiated with γ-rays at 0.3 Gy and 2 Gy,the possibility of ultra-fractionated radiotherapy is discussed in this paper.According to calculations,it is found that if the difference in cell survival between target tumor and adjacent normal tissue is up to 3%,radiotherapy using HRS would be realized through ultra-fractionation.Furthermore,the low-dose response is time-dependent.After analyzing this phenomenon,it was pointed that there would be a correlation between fractionation interval and the duration of cell G2 phase.更多还原