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¹²C⁶⁺离子辐照人胃癌细胞系BGC823的氧效应研究

Oxygen Effect in ¹²C⁶⁺ Irradiation of BGC823 Cells

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【Author】 JING Xi-gang~(1,2),LI Wen-jian~(1),YANG Jian-she~(1),GUO Chuan-ling~(1,2),CHU Wei~(3),JIN Xiao-dong~(1),WANG Ju-fang~(1),ZHOU Li-bin~(1,2)(1 Institute Modern Physics,Chinese Academy of Sciences,Lanzhou 730000, China;2 Graduate School of Chinese Academy of Sciences,Beijing 100049,China;3 Life Science School of Northwest University,Xi’an 710069,China)

【机构】中国科学院近代物理研究所；西北大学生命科学学院；中国科学院近代物理研究所甘肃兰州730000；中国科学院研究生院；北京100049；甘肃兰州730000；陕西西安710069；

【摘要】以体外培养的人类胃癌细胞系BGC823为材料,用兰州重离子加速器提供的能量为20MeV/u的12C6+离子,分别在富氧(95%O2+5%CO2)和自然条件下辐照细胞,测得这种离子的氧增比近似为1,说明在中等能量区12C6+离子有很低的氧效应。更多还原

【Abstract】 Gastric tumour BGC823 cells cultured in natural and rich oxygenic(95% O₂+5% CO₂) environment are irradiated with energy of 20 MeV/u ¹²C⁶⁺ ions at HIRFL.Average OER≈1 is deduced from survival curves for cells in natural and rich oxygenic environment. This relatively low OER value indicates that medium energy carbon ions are suitable for the cancerous therapy.更多还原