【摘要】 【目的】观察埃索美拉唑和阿奇霉素联合治疗,幽门螺杆菌(Hp)感染的疗效。【方法】120例Hp阳性患者,随机分为治疗组(A组)和对照组(B组)。A组给予埃索美拉唑20mg,阿奇霉素0.25g,均2次/d,共7d;B组给予经典Hp根除治疗方案:奥美拉唑20mg,阿莫西林1.0g,替硝唑0.4g,均2次/d,共7d;7d后分别继续单独使用埃索美拉唑或奥美拉唑20mg,1次/d,连续7d。于用药前1d,用药后d1,d3,d7,按标准对上腹痛,反酸进行评分,其中上腹痛从严重程度和发作频率两个方面进行评估。记录患者有无出现不良反应。治疗结束后4周做14C-UBT检查,了解Hp根除情况。【结果】A组上腹痛消失率用药d1为56.1%,d3为89.4%;B组用药d1为21.4%,d3为60.7%,两组比较差异有显著性(P<0.05);A组反酸消失率用药d1为59.6%,d3为93.0%;对照组用药d1为19.6%,d3为64.3%,两组比较差异有显著性(P<0.05);服药d7,A组上腹痛、反酸消失率分别为98.2%、98.2%,B组亦分别为96.4%、94.6%,两组比较差异无显著性(P>0.05)。A组、B组HP根除率分别为91.2%(52/57)、91.1%(51/56)(P>0.05)。不良反应发生率两组分别为8.7%(5/57),10.7%(6/56),所有患者均未出现明显不良反应。【结论】埃索美拉唑和阿奇霉素二联疗法是一种高效、安全、经济的根除Hp方案。更多还原

【Abstract】 [Objective]To study the efficiency of combined therapy of asomeprazole and azithromycin on eradication of Helicobacter Pylori.[Methods]One hundred twenty patients with established H. Pyloryi. infection were randomly divided into 2 groups:group A was the treating group while group B in control.Group A received asomeprazole 20mg bid plus azithromycin 0.25g bid for 7 days;Group B received the classical therapy on eradication of Helicobacter Pylori:omeprazole 20mg bid plus amoxicillin 1.0 bid and tinidazole 0.4 bid for 7 days;Group A and Group B were respectively given asomeprazole or omeprazole 20mg qd for the following continous 7 days.Acid regurgitation and upper abdominal pain were scored according to the criteria one day before using drugs and the first ,the third,the seventh day after using drugs,while upper abdominal pain was evaluated and recorded in severity ,and frequency. Helicobacter Pylori status was determined by 14C urea breath test(~ 14 C-UBT)4 weeks after treating.[Results]The percentages of upper abdominal pain disappearance at the first day and the third day were 56.1% ,89.4%in group A and 21.4% ,60.7%in gourp B,with statistical difference(P<0.05) The treating group achieved better results than the control group(P<0.05).The percentages of acid regurgitation disapperance at the first day and the third day were 59.6%,93.0%(group A) and 19.6%,64.3%(group B),with statistical difference(P<0.05) .The percentages of upper abdominal pain disapperance and acid regurgitation disapperance at the seventh day of the therapy were respectively 98.2%,98.2% in group A, 96.4%,94.6% in group B,with no statistical difference(P>0.05). Helicobacter Pylori was eradicated in 52 of 57 patients in group A(91.2%)and in 51 of 56 patients in group B(91.1%) after the treatment,with no statistical difference (P>0.05).Percentage of side effects were 8.7%(5/57) in group A and 10.7%(6/56)in group B.All patients had no severe side effects.[Conclusion]The combined therapy of asomeprazole and azithromycin is highly effective in eradicating Helicobacter Pylori.This regimen is safe,reliable and economical.更多还原