【摘要】 目的:研究应用阿托伐他汀(atorvastatin)对急性冠脉综合征(acute coronary syndromes ACS)患者减少炎症反应、稳定斑块的作用。方法:选定ACS患者51例,稳定型心绞痛(SA)患者15例及正常对照组20例。随机将ACS患者分为阿托伐他汀治疗组(27例)和常规治疗组(24例),比较各组间血清基质金属蛋白酶-2(MMP-2)及金属蛋白酶组织抑制剂-2(TIMP-2)的水平变化。结果:ACS组与SA组及正常对照组之间血清MMP-2、TIMP-2及MMP-2/TIMP-2水平相比差异有统计学意义,两治疗组治疗后血清MMP-2、TIMP-2水平相比差异有统计学意义。结论:阿托伐他汀可降低ACS患者血清MMP-2水平,升高TIMP-2水平,减少冠状动脉粥样斑块基质成分的降解和炎症反应,从而起到稳定动脉粥样硬化斑块的作用。更多还原

【Abstract】 Objective: To investigate the influences of atorvastatin on serum MMP2,TIMP-2 and MMP-2/TIMP-2 levels of patients with acute coronary syndrome(ACS).Methods: There were 51 patients with ACS and 15 patients with SA.Meanwhile,20 cases of age matched control individuals were selected.Then 51 patients with ACS were randomly divided into two groups: Atorvastatin treatment group and regular treatment group.The serum level of MMP-2 and TIMP-2 were compared among all groups.Results: There was significant difference in serum level of MMP-2 and TIMP-2 between ACS group and SA group and control group.There was significant difference in serum level of MMP-2 and TIMP-2 between atorvastatin treatment group and regular treatment group after treatment.Conclusion: atorvastatin could decrease the breakdown of matrix collagen and reduce inflammatory reaction,and it might have a beneficial effect on steadying the plaque.更多还原