【摘要】 目的:观察低剂量十一酸睾酮(TU)对心肌梗死后慢性心力衰竭(HF)雄性大鼠血清白介素-10(IL-10)水平的影响。方法:对120只健康雄性SD大鼠随机行冠状动脉结扎(n=105)或假手术(PS,n=15)。6周后将存活的44只模型鼠随机分为2组:心力衰竭+TU治疗组(HF+TU组,n=22)给予TU 5 mg/kg.2周肌肉注射;心力衰竭组(HF组,n=22),给予安慰剂。用药12周后测定血清睾酮(T)及IL-10浓度。结果:HF组雄鼠血清T水平明显低于PS组(153.91±77.45 vs 475.28±161.37 ng/d1,P<0.05),HF+TU组T浓度与PS组无显著性差异(415.50±59.22 vs 475.28±161.37 ng/dl,P>0.05)。HF组较PS组血清IL-10浓度明显下降(4.90±1.32 vs 7.30±2.14 pg/ml,P<0.05)。HF+TU组较HF组血清IL-10浓度显著升高(6.55±2.11 vs4.90±1.32 pg/m1,P<0.05)。HF+TU组与PS组血清IL-10浓度无显著性差异(6.55±2.11 vs 7.30±2.14 pg/m1,P>0.05)。结论:低剂量睾酮可提高心肌梗死后慢性心衰雄性大鼠血清IL-10水平。更多还原

【Abstract】 Objective: To investigate the effect of low dose testosterone undecanonate(TU) on serum interleukin-10(IL-10) level in male rats postinfarction heart failure(HF)model.Methods: 120 SD male rats were randomly assigned to ligation of coronary artery(n=105) or pseudo operation(PS,n=15).6 weeks later,44 survived model rats were randomly divided into 2 groups: HF+TU group(n=15) treated with TU 5 mg/kg per 2 weeks intramuscular injection;HF group(n=22) treated with placebo.Serumtestosterone(T) and IL-10 level were determined after treatmemt for 12 weeks.Results: Serum testosterone level in HF group were significantly lower than which in the PS group(153.914±77.45 vs.475.284±161.37 ng/dl,P<0.05),serum testosterone level in HF+TU group had no significant change compared with that in PS group(415.504±59.22 vs.475.28±161.37 ng/dl,P>0.05).Serum IL-10 was significantly lower(4.904±1.32 vs.7.30±2.14 pg/ml,P<0.05) in HF group compared with that in PS group;After TU therapy,serum IL-10 level increased markedly(6.554±(2.11 vs.4.904)±1.32 pg/ml,P<0.05).No significant change was found of serum IL-10 level in HF+TU groupaccording to that in PS group(6.55±2.11 vs.7.304±2.14 pg/ml,P>0.05).Conclusion: Low dose testosterone induced an increase in IL-10 in male rats postinfarction HF model.更多还原