【摘要】 目的观察短暂性脑缺血发作(TIA)患者血浆内皮素(ET)和降钙素基因相关肽(CGRP)的水平变化。方法选择50例最近一次脑缺血发作<72h的TIA患者,放射免疫法测定血浆ET和CGRP水平,测定血小板计数、血小板最大聚集率、胆固醇、甘油三酯、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇水平。50例门诊体检健康人作正常对照。结果TIA患者血浆ET和CGRP水平比正常对照组增高,且重度患者高于轻度患者(P均<0.05)。血浆ET和CGRP水平与血小板最大聚集率呈正相关(r分别为0.32,0.36,P均<0.05)。结论TIA的发病与内皮细胞损伤和血浆ET及CGRP水平增高有关。更多还原

【Abstract】 Aim: To observe the changes of plasma endothelin(ET) and calcitonin gene-related peptide(CGRP) in patients with transient ischemic attack (TIA). Methods: Fifty patients with TIA (the last episode < 72 h) and 50 controls were selected. Plasma ET and CGRP were analyzed by radioimmunoassay. Platelet count, platelet aggregation, cholesterol, triglyceride, high and low density lipoprotein cholesterol were determined. Results: Plasma ET and CGRP in patients with TIA were significantly higher than those in controls. Plasma ET and CGRP were positively correlated with platelet aggregation (r=0.32, 0.36, P<0.05).Conclusion: TIA is associated with endothelial injury and the ascension of ET and CGRP.更多还原