【摘要】 目的:检测食管鳞癌组织中胰岛素样生长因子-Ⅱ(IGF-Ⅱ)蛋白的表达。方法:应用免疫组织化学S P法,检测54例食管鳞癌组织,22例癌旁不典型增生组织及54例正常食管黏膜组织中IGFⅡ蛋白的表达,并分析IGF-Ⅱ表达与食管鳞癌浸润、转移的关系。结果:食管鳞癌组织、癌旁不典型增生组织及正常食管黏膜组织中IGF-Ⅱ蛋白的阳性表达率分别为85.19%、63.64%和22.22%,任意2者间差异有统计学意义(P<0.01)。IGF-Ⅱ蛋白的阳性表达与食管鳞癌的浸润深度和淋巴结转移有关(P<0.05)。结论:IGF-Ⅱ蛋白在食管鳞癌组织中高表达与食管鳞癌的发生发展、浸润转移有关。更多还原

【Abstract】 Aim: To investigate the expressions of IGF-Ⅱ in esophageal squamous cell carcinoma tissue.Methods:The expression of IGF-Ⅱin 54 cases of esophageal squamous cell carcinoma tissue, 22 cases of non-typical hyperplasia tissue adjacent to carcinoma and 54 cases of normal mucosa tissue was detected by immunohistochemistry SP method, and the relation between the expressions of IGF-Ⅱand the invasion and metastasis of esophageal squamous cell carcinoma was analyzed.Results: The positive rates of IGF-Ⅱin esophageal squamous cell carcinoma tissue, non-typical hyperplasia tissue and normal esophageal mucous tissue were 85.19%,63.64% and 22.22%,respectively, and the difference between any two groups was statistically significant(P<0.01). IGF-Ⅱwas related to the depth of invasion and the metastasis of lymph node of esophageal squamous cell carcinoma.(P<0.05).Conclusion: The high expression of IGF-Ⅱ is related to the cacinogenesis and development of esophageal squamous cell carcinoma.更多还原