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煤焦沥青接触者血清SOD、MDA及唾液酸检测

Detection of serum SOD,MDA, and SA in workers exposed to coal tar pitch

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【Author】 ZHANG Junping 1) ,ZHANG Qiao 2) ,ZHOU Fang 2) ,MA Yongzhi 1) ,LI Shi’en 2) ,LI Zhiyuan 2) ,ZHAO Yibo 2) 1)Anyang Institute of Occupational Disease Prevention and Cure,Anyang 455000 2)Department of Labor Health,College of Public Health,Zhengzhou University, Zhengzhou 450052

【机构】安阳市职业病防治所；郑州大学公共卫生学院劳动卫生学教研室；郑州大学公共卫生学院劳动卫生学教研室安阳455000；郑州450052；安阳455000；

【摘要】目的检测煤焦沥青接触者血清超氧化物歧化酶总量(SOD)、丙二醛(MDA)及唾液酸(SA)水平,探讨职业性肺癌的早期预警指标。方法焦炉工55人(接触组),某高校教师、学生及职工40人(非接触组),采用硫代巴比妥酸法测定其血清MDA水平,采用黄嘌呤氧化快速比色法测定T-SOD水平,采用比色法测定SA水平。结果接触组血清MDA、SA含量高于非接触组(P<0.001),血清T-SOD含量低于非接触组(P<0.001)。接触组不同年龄及工龄组之间各指标差异均无统计学意义(P>0.05)。结论煤焦沥青可导致接触者生物膜的明显损伤。SOD、MDA、SA等指标可用于职业性肺癌的早期预警。更多还原

【Abstract】 Aim: To explore early monitoring index of occupational lung cancer. Methods: Serum levels of MDA,total SOD (T-SOD) and SA of 55 coke oven workers(exposure group) and 40 controls (unexposure group) were determined. Results: Compared with that of unexposure group, the serum levels of MDA and SA of exposure group were significantly higher(P<0.001), and the T-SOD levels were significantly lower(P<0.001). There were no significant differences in the above parameters between different ages and different working ages in exposure group(P>0.05). Conclusion: Coal tar pitch can result in obvious biomembrane damage of the exposed workers. Indexes such as MDA,T-SOD and SA can be used to alarm occupational lung cancer at early stage.更多还原

【关键词】煤焦沥青；血清； MDA； SA； SOD；生物膜损伤；
【Key words】 coal tar pitch； serum； MDA； SA； SOD； biomembrane damage；

【文献出处】郑州大学学报(医学版) ,Journal of Zhengzhou University(Medical Sciences) , 编辑部邮箱 ,2006年02期

【分类号】R131
【被引频次】11
【下载频次】156

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