【摘要】 目的测定2型糖尿病并发冠心病患者对氧磷酯酶-1(PON1)活性和丙二醛水平。方法分别采用紫外分光光度法和比色法测定正常对照组(NC组,n=40)、单纯糖尿病组(DM组,n=47)及糖尿病并发冠心病组(DMCHD组,n=43)血清PON1活性及丙二醛(MDA)水平,计算并测定体质量指数(BMI)及血脂水平。结果3组间比较,血脂水平差异无统计学意义(P>0.05);与NC组、DM组比较,DMCHD组BMI增大(P均<0.05)。DM组及DMCHD组PON1活性均低于NC组,MDA水平均高于NC组(P均<0.05),DMCHD组PON1活性低于DM组,MDA水平高于DM组(P均<0.05)。且PON1活性与MDA水平呈负相关(r=-0.544,P<0.01)。结论血清PON1活性降低和MDA水平升高是糖尿病并发冠心病的独立危险因素。更多还原

【Abstract】 Aim: To detect the paraoxonase(PON1) activity and MDA level in DM with coronary heart disease(DMCHD) patients. Methods: PON1 activity and MDA level were determined with spectrophotography and colorimetric method in DM patients(n=47), DMCHD patients(n=43) and control subjects(n=40).BMI and serum TC,TG,HDL,LDL levels were detected.Results:There were no differences of TC,TG,HDL,and LDL levels among 3 groups (P>0.05). Compared with control and DM groups,BMI of DMCHD group increased significantly (P<0.05). PON1 activity of DM group and DMCHD group was lower than that of control group(P<0.05). PON1 activity of DMCHD group was lower than that of DM group(P<0.05). MDA level of DM group and DMCHD group was higher than that of control group (P<0.05).MDA level of DMCHD group was higher than that of DM group (P<0.05).PON1 activity was negatively correlated with MDA level (r=-0.544, P<0.01).Conclusion:The decreased serum PON1 activity and increased MDA level are independent risk factors of DMCHD.更多还原