【摘要】 从苯酚、对氨基苯甲酸和2-甲硫基-4,6-二氯嘧啶出发,建立了包含取代、氧化和缩合等7步反应的丙酯草醚除草剂微量制备方法。最终产物经制备HPLC纯化,其收率为53%,化学纯度大于98%,用MS(EI)、HPLC-MS1、H-NMR、UV等方法确认了丙酯草醚的结构。所建立的丙酯草醚微量制备方法,为放射性同位素标记丙酯草醚的合成奠定了基础。更多还原

【Abstract】 ZJ273,propyl 4-[2-[(4,6-dimethoxy-2-pyrimidinyl)oxy]benzylamino]benzoate,is a novel herbicide.The microsynthetic method of the compound was developed from 4,6-dimethoxy-2-pyrimidine,propyl(4-benzylamino) benzoate and phenol,and then purified by preparative-HPLC.The yield of end product was 53%.Its chemical structure was characterized by means of()~1H-NMR,MS,UV,and its chemical purity was determined to be exceed 98% by HPLC.The microsynthetic method of propyl 4[2-[(4,6-dimethoxy-2-pyrimidinyl)oxy] benzylamino]benzoate developed sets up a basis to synthesize the radioisotopic labeled target compound.更多还原