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甲硫嘧磺隆原药的合成工艺研究
Synthesis of Sulfonylurea Herbicide 2-[[[[(4-Methoxy-6-methylthio-2-pyrimidinyl) amino]carbonyl]amino]sulfonyl]Benzoic Acid Methyl Ester
【摘要】 甲硫嘧磺隆(C9908)是湖南化工研究院对磺酰脲类化合物进行结构修饰而得到的新除草剂。探讨了以2-氨基-4-甲氧基-6-甲硫基嘧啶(AOTP)和2-甲酸甲酯苯磺酰异氰酸酯(MCBI)为原料合成标题化合物的方法,对影响反应的主要因素进行了研究,获得了优化反应条件:n(AOTP)n∶(MCBI)=11∶.75、温度60～70℃、时间1.5h。优化条件下,收率高于93%,产品含量高于96%。
【Abstract】 2-[[[[(4-methoxy-6-methylthio-2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]Benzoic acid methyl ester(C9908) was a novel sulfonylurea herbicide with high herbicidal activity that discovered by Hunan Research Institute of Chemical Industry The herbicide C9908 was synthesized from 2-amino-4-methoxy-6-methylthiopyrimidine(AOTP)and 2-methoxycarbonyl-benzenesulfonyl isocyanate(MCBI).The major factors which influenced the reaction were studied,and the optimum process conditions were obtained as follow:reaction temperature was 60~70℃,reactive time 1.5 h and the mole ratio of AOTP and MCBI 1 ∶ 1.75.Under optimum conditions,the yield and purity of product is about 93%,and 96%,respectively.
【Key words】 2-[[[[(4-methoxy-6-methylthio-2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]benzoic acid methyl ester； 2-amino-4-methoxy-6-methylthiopyrimidine； herbicide； synthesis；
- 【文献出处】 精细化工中间体 ,Fine Chemical Intermediates , 编辑部邮箱 ,2006年06期
- 【分类号】TQ457
- 【被引频次】11
- 【下载频次】191