【摘要】 通过固相熔融的方法,使4,4′-联吡啶与磺酸酯或苄溴进行反应.结果表明,将反应固体混合物加热到融化,在30 min内完成反应.通过控制反应物的投料比,可以高选择性的产生单取代或双取代4,4′-联吡啶衍生物.当4,4′-联吡啶与磺酸酯或苄溴摩尔比为1.0∶2.1时,生成双取代产物,收率近100%;当摩尔比为10∶1.0时,生成单取代产物,收率达90%.更多还原

【Abstract】 The reaction of tosylate or benzyl bromide containing stopper with 4,4′-bipyridine was carried out under solvent-free.The results showed that the reaction could be completed when the solid mixture was heated to melt and kept for 30 min.The reaction could give N-substituted or N,N-disubstituted derivatives of 4,4′-bipyridine according to the difference of mol ratio of reactants.When the mol ratio of tosylate to 4,4′-bipyridine was 2.1∶1.0,the reaction gave N,N-disubstituted derivatives in almost 100% yields,and when the mol ratio was 1.0∶10,it gave N-substituted derivatives in about 90% yields.更多还原