【摘要】 建立了克拉霉素中丙酮溶剂残留量的测定方法.采用顶空气相色谱法,氢火焰离子化检测器(FID),以二甲基甲酰胺(DMF)为溶剂,HP-FFAP弹性石英毛细管柱为色谱柱(30 m×0.25mm,0.25μm),氮气为载气,分流比为1∶60,进样口温度为200℃,检测器温度250℃,柱温采用程序升温.丙酮的质量浓度在0.002~4 g.L-1的范围内呈良好的线性关系(r=0.999 5),回收率为99.2%(RSD=1.9%)检出限小于2.0 mg.L-1.更多还原

【Abstract】 A method for the determination of residue of acetone solvent was established using headspace gas chromatography.The solvent used in this determination was DMF,the column used was HP-FFAP（30m×0.25mm,0.25μm）, the carrier gas used was nitrogen with split ratio of 1∶60,the injector temperature was 200℃,the detector temperature was 250℃,and the column temperature was programmed in this determination process.Acetone showed a good linear relationship in the range of 0.002—4 g·L^-1 in sample solution（r=0.9995）,recovery rate was 99.2%（RSD=1.9%）,and detecting limit was less than 2.0 mg·L^-1.更多还原