【摘要】 目的评价高温低渗持续腹腔灌注化疗治疗恶性腹水的疗效及毒性。方法晚期肿瘤合并恶性腹水40例,采用5-Fu1.5g/m2,加入低渗液(蒸馏水)中,高温持续腹腔灌注治疗,每10天治疗1次,每3次为1疗程。结果全组40例中,治疗完全缓解18例,部分缓解12例,稳定6例,进展4例,总有效率75%。主要毒副反应为腹泻,患者耐受性良好。结论高温低渗持续腹腔灌注化疗对于晚期肿瘤合并恶性腹水患者具有疗效高、毒副反应少的特点,值得临床上进一步推广使用。更多还原

【Abstract】 Objective To evaluate the both clinic effect and adverse reaction of malignant ascites treated by continuing abdominal perfusion with heated hypotonic fluid and 5-fluorouracil. Methods 40 patients with malignant ascites were treated with continuing abdominal perfusion with heated hypotonic fluid and 5-fluorouracil. The chemotherapy was repeated every 10 days. Each patient was given at least 3 cycles.Results There were 18 CR, 12 PR, 6 NC and 4 PD in the group ,The overall response rate was 75%. The main adverse effect was diarrhea.The adverse effect was tolerable.Conclusions It is an ideal method to use continuing abdominal perfusion with heated hypotonic fluid and 5-fluorouracil for malignant ascites and is worthy to be recommended.更多还原