【摘要】 目的研究血清纤维化指标透明质酸(HA)、Ⅳ型胶原(Ⅳ)及层黏蛋白(LNC)与慢性乙型肝炎患者肝组织炎症程度与纤维化分期之间的关系。方法用放射免疫法测定150例慢性乙肝患者血清HA、ⅣC、LN水平,同时行肝组织活检,对肝组织炎症分级及纤维化分期,分析上述指标与肝纤维化及炎症之间的关系。结果上述3项指标随着肝脏炎症及纤维化程度的加重而上升,呈正相关。尤其在慢性重度肝炎时处于最高水平(P<0.01)。结论血清HA、LN、ⅣC水平不同程度反映肝纤维化和肝脏炎症,可做为反映肝脏炎症和纤维化程度的参考指标。更多还原

【Abstract】 Objective To evaluate the diagnostic value of serum liver fibrosis markers by analyzing the correlation between liver fibrosis stage in patient with chronic hepatitis B and serum liver fibrosis makers,such as hyaluronate,laminin and type Ⅳ collagen.Methods we reviewed 150 patients with chronic liver diseases and compared their serun markers of liver fibrosis with liver pathological findings.Serum concentrations of hyaluronate,laminin and type Ⅳ collagen were detected by radioimmune assay,These level were compared with the pathological grading and staging of those patients.Results Serum concentrations of hyaluronate,laminin and type Ⅳ collagen were remarkably increase with the progression of the disease,and reached the highes levels in chronic severe hepatitis(P<0.01).Conclusion Serum concentrations of hyaluronate,laminin and type Ⅳ collagen could reflect the status of hepatic fibrosis and inflammation.These serum markers were suitable for diagnosing hepatic fibrosis inflammation.更多还原