节点文献

聚L-乳酸药用辅料的吸湿特性

Moisture Absorption Properties of Poly (L-lactic acid) Used as an Excipient

  • 推荐 CAJ下载
  • PDF下载
  • 不支持迅雷等下载工具,请取消加速工具后下载。

【作者】 马建华鲍时根朱玉俊

【Author】 MA Jian-hua~1,BAO Shi-gen~2,ZHU Yu-jun~2(1.Dept.of Chemical Engineering,Anhui University of Science and Technology,Huainan Anhui 232001,China;2.Institute of Controlled Release Drug,Hefei University of Technology,Hefei Anhui 230009,China)

【机构】 安徽理工大学化学工程系合肥工业大学控释药物研究室合肥工业大学控释药物研究室 安徽淮南232001安徽合肥230009

【摘要】 考察聚L-乳酸药用辅料在潮湿空气和水中的吸湿特性。测定了不同分子量的粉料与片状试样在不同相对湿度的空气与蒸馏水中的吸湿量与时间的关系,得出平衡湿含量,并计算出水分在试样中的扩散系数。粉料与片状试样在不同湿度的湿空气中的平衡湿含量均小于1%,在水中的平衡湿含量小于11%,辅料分子量对吸湿性能有一定影响。吸湿过程遵从F ick扩散机理。

【Abstract】 To evaluate the moisture absorption properties of poly(L-lactic acid)(PLLA) in the moist air and water,PLLAs with different molecule weight as experimental materials were exposed to moist air with different relative humidity and immersed in distilled water,and moisture absorption tests were performed to determine the relationship between moisture content and time.The equilibrated moisture contents were measured and the moisture diffusibilities into the samples were calculated with the results obtained from the tests above.No mater what powdery PLLA and PLLA tables were exposed to moist air with different relative humidity,values of the equilibrated moisture contents were all below 1% and the values below 11% when immersed in the water.Molecule weight of PLLA influenced on moisture absorption properties to a certain extent.The process of moisture absorption matches Fickian diffusion mechanism.

【基金】 安徽省“十五”科技攻关资助项目(01012023)
  • 【文献出处】 安徽理工大学学报(自然科学版) ,Journal of Anhui University of Science and Technology(Natural Science) , 编辑部邮箱 ,2006年02期
  • 【分类号】TQ460.4
  • 【下载频次】125
节点文献中: 

本文链接的文献网络图示:

本文的引文网络