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尿微量蛋白在糖尿病早期肾脏损伤诊断中的作用

Study on the diagnostic value of urine microprotein in early damage of kidney

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【作者】 王智斌刘新

【Author】 WANG Zhi-bin,LIU Xin.(Sichuan Provincial People’s Hospital,Sichuan 610072,China)

【机构】 四川省人民医院检验科四川省人民医院检验科 四川成都610072四川成都610072

【摘要】 目的探讨尿微量蛋白(M A)检测对早期肾脏损伤的诊断价值。方法M A、1α微球蛋白(1α-M)、转铁蛋白(TRF)、IgG测定用速率散射比浊法;尿蛋白定性测定用尿11联试纸。结果糖尿病组与对照组比较,尿蛋白定性、尿M A、1α-M、TRF、IgG检测结果有显著性差异。初期肾病组的尿M A、1α-M、TRF阳性率相近,明显高于尿蛋白定性、尿IgG。临床肾病组的尿蛋白定性、尿M A、1α-M、TRF检测阳性率无显著性差异。结论尿M A,1α-M,TRF是诊断早期肾脏损伤的灵敏的指标。

【Abstract】 Objective To investigate the diagnostic value of urine microproteins in early kidney damage.Methods MA,α1-M,TRF and IgG in urine were detected with rate nephelometry and protein in urine was qualitatively measured with uropaper.Results Concentration of MA,α1-M,TRF and IgG in urine was significantly higher in diabetes group than in control group.Positive rate of MA,α1-M,and TRF was not obviously different,but obviously higher than that of qualitative urine protein and IgG in the diagnosis of the early nephropathy group.Qualitative urine protein,urine MA,α1-M and TRF were not statistically different in clinical nephropathy group.Conclusion Urine MA,α1-M,TRF in urine are sensitive indexes in diagnosis of kidney damage.

【关键词】 糖尿病肾脏损伤微量蛋白诊断
【Key words】 DiabetesDamage of kidneyMicroproteinDiagnosis
  • 【文献出处】 淮海医药 ,Journal of Huaihai Medicine , 编辑部邮箱 ,2006年02期
  • 【分类号】R587.2
  • 【下载频次】45
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