【摘要】 1-硝基-2-(2,6-二氨基-4(3H)-氧代嘧啶-5-基)-4-(4-乙氧甲酰苯基)丁烷是合成培美曲塞二钠的关键中间体。研究了以4-碘苯甲酸,2,6-二氨基-4-羟基嘧啶为原料,经酯化,加成,缩合,消除,加成,得目标产物。本法收率高,适合工业化生产。更多还原

【Abstract】 1-nitro-2-(2,6-diamino-4(3H)-oxopyrimidin-5-yl)-4-(4ethoxycarboxyphenyl)butane,a key mediate of pemetrexed disodium,was synthesized from 4-iodobenzoicacid and 2,6-diamino-4(3H)-oxopyrimidine by esterification,addition,condensation,elimination,addition reaction.The method is good for industry with high yield.更多还原