【摘要】 目的:探讨外周血嗜酸性粒细胞计数(EOS)、转化生长因子β1(TGβ1)及白细胞介素4(IL-4)在儿童哮喘发病中的作用。方法:将60例哮喘患儿分为危重组(21例)及普通组(39例),应用双抗体夹心ELISA法对60例发作期及48例缓解期哮喘患儿及30例正常儿童进行血清IL-4、TGβ1水平测定,并用血球分析仪进行嗜酸性粒细胞计数。结果:哮喘发作期血清TGβ1较缓解期及正常对照组低,血清IL-4及嗜酸性粒细胞计数较缓解期及正常对照组高;危重组血清TGβ1较普通组低,血清IL-4及嗜酸性粒细胞计数较普通组高。结论:外周血嗜酸性粒细胞计数、转化生长因子β1(TGβ1)及白细胞介素4(IL-4)参与了哮喘的发病过程,并与疾病的严重程度密切相关。更多还原

【Abstract】 Objective: To explore the role of EOS、TGβ₁ and IL-4 in the pathogenesis of asthmatic children and their clinical significances.Method: TGβ₁ and IL-4 of 60 cases in acute attack group and that of 48 cases in remission group,and that of 30 healthy children in normal control group were detected by Sandwich ELISA.EOS was detected by blood cell analyzer.Result: The serum TGβ₁ level was lower in acute attack group than that in remission group.The serum 1IL-4 and EOS were higher in acute attach group than that in remission group.The serum TGβ₁ level was lower in risk group than that in ordinary group.The serum IL-4 and EOS were higher in risk attach group than that in ordinary group.Conclusion: EOS、TGβ₁ and IL-4 played a role in pathogenesis.There was certain correlation between serum levels of EOS、TGβ₁ and IL-4 with serious degree in asthmatic children.更多还原