【摘要】 目的:探讨红细胞平均体积(MCV)、平均红细胞血红蛋白量(MCH)、红细胞体积分布宽度(RDW)并结合HbA2、HbF检测结果在筛查围产期地中海贫血中的应用价值。方法:采用自动血细胞分析仪分别对120例地中海贫血患者、90例非地中海贫血者和60例对照者进行MCV、MCH、RDW测定,层析法测定HbA2,碱变性法测定HbF,并对结果作相关统计学分析。同时将部分筛查结果与地中海贫血基因诊断(PCR)结果进行比较,分析筛查方法的敏感度和特异度。结果:地中海贫血组MCV、MCH、RDW与对照组比较有显著性统计学意义(P<0.01);对照PCR结果,MCV、MCH、RDW诊断轻型地中海贫血的敏感性98.3%,特异性76.7%。结论:MCV、MCH、RDW可作为筛查围产期地中海贫血的有效指标,可疑者建议做进一步的检查,以明确诊断。更多还原

【Abstract】 Objective:To study the value of the tests of mean corpuscular volume（MCV） 、mean corpuscular hemoglobin（MCH）、red blood cell distribution width（RDW）and hemoglobin zones analyses for the diagnosis of halassemia1.Methods:MCV、MCH and RDW were detected from 120 cases with thalassanemia,90 cases with non-thalassanemia and 60 cases control by automatic blood analyzer system.HbA₂ were detected by chromatography,HbF were analyzed by anti-base test,and compared with the test of gene diagnosis（PCR test）in order to evaluating their sensitivity and specificity.Result:The results of MCV,MCH and RDW showed significantly different between the thalassanemia group and the control group（P<0.01）.The sensitivity and specificity of MCV,MCH,RDW was 98.8% and 73.6% comparing with PCR.Conclusion:MCV,MCH and RDW could use as significance level on screening thalassanemia in prenatal diagnosis.更多还原