【摘要】 对2,3-二甲基-4-氯吡啶-N-氧化物(4)的合成工艺进行了改进。以2,3-二甲基吡啶为原料,经氧化(钨酸钠为催化剂,双氧水为氧化剂,收率96.5%),硝化(65%的浓硝酸为硝化剂,收率86.3%,纯度99.0%)及氯化(乙酰氯为氯化剂,收率86.8%,纯度98.6%)合成了4,总收率72.2%,4的结构经1H NMR表征。更多还原

【Abstract】 4-Chloro-2,3-dimethylpyridineN-oxide(4) were synthesized from 2,3-dimethylpyridine by the reaction of oxidation(sodium tungstate as a catalyst,hydrogen peroxide as a oxidant,yield of(96.5%)),nitration(65% nitric acid as a nitrating agent,yield of 86.3%,purity of 99.0%) and chlorination(acetyl chloride as a chloridizing agent,yield of 86.8%,purity of 98.6%).The overall yield reached 72.2%.The structure of 4 was identified by ~1H NMR.更多还原